Implantation of octacalcium phosphate (OCP) in rat skull defects enhances bone repair

Shinji Kamakura, Yasuyuki Sasano, H. Homma, Osamu Suzuki, M. Kagayama, K. Motegi

研究成果: Article査読

96 被引用数 (Scopus)

抄録

Synthetic octacalcium phosphate (OCP) enhances bone formation if implanted into the subperiosteal region of murine bone. Such implanted OCP may be resorbed and replaced by bone with time. We hypothesized that OCP could be used as an effective bone substitute. To test this hypothesis, we designed the present study to investigate if bone repair in a rat skull defect is enhanced by the implantation of OCP. Rats were divided into two groups: OCPtreated animals and untreated controls. Six rats from each group were fixed at 4,12, and 24 weeks after implantation. A full-thickness standardized trephine defect was made in the parietal bone, and synthetic OCP was implanted into the defect. After being examined radiographically, the specimens were decalcified and processed for histology. OCP implantation significantly promoted bone repair compared with the controls. A statistical analysis showed an increase in the area of radiopacity within the skull defect between week 4 and week 12. Histologically, bone was formed on the implanted OCP and along the defect margin at \veek 4. At week 12, the implanted OCP was surrounded by newly formed bone. At week 24, the defect was almost completely filled with bone. In the control, bone formation was observed only along the defect margin. The present results demonstrate that OCP could be used as an effective bone substitute.

本文言語English
ページ(範囲)1682-1687
ページ数6
ジャーナルJournal of Dental Research
78
11
DOI
出版ステータスPublished - 1999 1 1

ASJC Scopus subject areas

  • Dentistry(all)

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