Impaired hair placode formation with reduced expression of hair follicle-related genes in mice lacking Lgr4

Yasuaki Mohri, Shigeki Kato, Akihiro Umezawa, Ryuhei Okuyama, Katsuhiko Nishimori

研究成果: Article

49 引用 (Scopus)

抜粋

We observed that Lgr4K5 KO mice had sparse head hair and focal alopecia behind their ears, as observed in tabby (Eda) and downless (Edar) mice, which are models of the human genetic disorder hypohidrotic (anhidrotic) ectodermal dysplasia (HED). Lgr4-deficient mice showed partial impairment in hair follicle development with reduced expression of Edar, Lef1, and SAA, which were essential for hair follicle morphogenesis, in the epidermis. Immunohistochemical analysis of Lgr4-/- mice epidermis using shh antibody showed reduced numbers of hair placodes, and we also detected higher phosphorylation of Smadl/5/8, which is required to suppress normal hair follicle induction. We suspected that Lgr4 might be a novel gene class regulating the development of hair follicles.

元の言語English
ページ(範囲)2235-2242
ページ数8
ジャーナルDevelopmental Dynamics
237
発行部数8
DOI
出版物ステータスPublished - 2008 8

ASJC Scopus subject areas

  • Developmental Biology

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