Immunoreactive adrenomedullin in human adrenal glands and adrenal tumors

F. Satoh, K. Takahashi, O. Murakami, Kazuhito Totsune, M. Sone, M. Ohneda, K. Abe, Y. Miura, T. Mouri

研究成果: Article査読

10 被引用数 (Scopus)

抄録

Adrenomedullin is a potent vasodilator peptide that was isolated from human pheochromocytoma. We developed a sensitive and specific radioimmunoassay for adrenomedullin and studied the presence of adrenomedullin in human adrenal glands and adrenal tumors, including pheochromocytoma. High concentrations of immunoreactive adrenomedullin were found in normal parts of adrenal glands (cortex and medulla) (12.6 ± 1.0 pmol/g wet wt, N = 7, mean ± SEM). High concentrations of immunoreactive adrenomedullin were also present in the tumor tissues of pheochromocytoma (4.5 ± 1.5 pmol/g wet wt, N = 11). Immunoreactive adrenomedullin was detected in some adrenocortical tumors, but these concentrations were much lower than those in the normal adrenal glands and pheochromocytomas. Reverse phase high-performance liquid chromatography of the normal adrenal gland and pheochromocytoma showed a peak eluting in the position of synthetic adrenomedullin 1-52. The present study has shown the presence of high concentrations of immunoreactive adrenomedullin in the normal adrenal glands and pheochromocytomas.

本文言語English
ページ(範囲)51-54
ページ数4
ジャーナルCancer detection and prevention
21
1
出版ステータスPublished - 1997 8 4

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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