Immunolocalization of liver receptor homologue-1 (LRH-1) in human breast carcinoma: Possible regulator of in situ steroidogenesis

Yasuhiro Miki, Colin D. Clyne, Takashi Suzuki, Takuya Moriya, Rie Shibuya, Yasuhiro Nakamura, Takanori Ishida, Nami Yabuki, Kunio Kitada, Shin ichi Hayashi, Hironobu Sasano

研究成果: Article

37 被引用数 (Scopus)

抄録

Liver receptor homologue-1 (LRH-1) belongs to a class of nuclear orphan receptor. We examined immunolocalization of LRH-1 in 106 breast carcinomas. LRH-1 immunoreactivity was detected in 43% of the invasive ductal carcinoma. It was negatively correlated with clinical stage, histological grade and HER2 status, and positively associated with sex-steroid receptors, steroidogenic acute regulatory protein, P450 side-chain cleavage, and 3β-hydroxysteroid dehydrogenase. LRH-1 immunoreactivity was also detected in 28% of the ductal carcinoma in situ. These results suggest that LRH-1 is frequently detected in breast carcinoma tissues, and plays important roles including the regulation of in situ steroidogenesis.

本文言語English
ページ(範囲)24-33
ページ数10
ジャーナルCancer Letters
244
1
DOI
出版ステータスPublished - 2006 11 28

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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