Immunohistochemical study of cytochrome P-45011 β-hydroxylase in human adrenal cortex with mineralo- and glucocorticoid excess

Hironobu Sasano, Mitsuhiro Okamoto, Nobuaki Sasano

研究成果: Article査読

42 被引用数 (Scopus)


Cytochrome P-450 specific for steroid 11 β-hydroxylation (P-45011 β) was immunohistochemically demonstrated in the adrenal glands of human, pig and bovine and of mineralo- and glucocorticoid excess using a specific monoclonal antibody against P-45011 β of bovine adrenocortical mitochondria. P-45011 β was present in all three cortical zones of the histologically normal adrenal glands of bovine, pig and human, particularly in the zona fasciculata (ZF) and reticularis (ZR). The P-45011 β immunoreactivity was intensive in cortical micronodules and inner ZF and ZR in Cushing's disease, and relatively intensive in the zona glomerulosa (ZG) and outer ZF in idiopathic hyperaldosteronism (IHA), corresponding to the sites of active steroidogenesis. In adenomas with Cushing's syndrome and primary aldosteronism, compact cells were generally stained well. In the adrenal glands attached to the adenomas, immunoreactivity was observed only focally in ZG cells but not in ZF and ZR cells.

ジャーナルVirchows Archiv A Pathological Anatomy and Histopathology
出版ステータスPublished - 1988 7 1

ASJC Scopus subject areas

  • 病理学および法医学


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