Immunohistochemical characterization, distribution and ultrastructure of lymphocytes bearing the gamma/delta T-cell receptor in the human gut

Kouhei Fukushima, Takayuki Masuda, Haruo Ohtani, Iwao Sasaki, Yuji Funayama, Seiki Matsuno, Hiroshi Nagura

研究成果: Article査読

17 被引用数 (Scopus)

抄録

The phenotypic characterization and distribution of lymphocytes bearing the gamma/delta T-cell receptor (TCR) in the human gut were investigated by an immunohistochemical technique. A mirror section technique and double staining method were used for the phenotypic analysis. Intraepithelial delta-positive cells were almost all CD8-positive and rarely negative for both CD4 and CD8. On the other hand, lymphocytes bearing TCR gamma/delta in the lamina propria were largely negative for both CD4 and CD8. The ratio of delta-positive to CD3-positive cells amongst intraepithelial lymphocytes was larger in the lower intestine. Deltapositive cells were also observed in paracortical areas of lymphoid follicles. Immunoelectron microscopic observation revealed granular structures in these delta-positive cells, which are also present in large granular lymphocytes. The role of lymphocytes bearing TCR gamma/ delta in mucosal immune responses in the human gut are discussed.

本文言語English
ページ(範囲)7-13
ページ数7
ジャーナルVirchows Archiv B Cell Pathology Including Molecular Pathology
60
1
DOI
出版ステータスPublished - 1991 12 1

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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