Immunohistochemical Biomarkers of Adrenal Cortical Neoplasms

Ozgur Mete, Sylvia L. Asa, Thomas J. Giordano, Mauro Papotti, Hironobu Sasano, Marco Volante

研究成果: Review article査読

20 被引用数 (Scopus)

抄録

Careful morphological evaluation forms the basis of the workup of an adrenal cortical neoplasm. However, the adoption of immunohistochemical biomarkers has added tremendous value to enhance diagnostic accuracy. The authors provide a brief review of immunohistochemical biomarkers that have been used in the confirmation of adrenal cortical origin and in the detection of the source of functional adrenal cortical proliferations, as well as diagnostic, predictive, and prognostic biomarkers of adrenal cortical carcinoma. In addition, a brief section on potential novel theranostic biomarkers in the prediction of treatment response to mitotane and other relevant chemotherapeutic agents is also provided. In the era of precision and personalized medical practice, adoption of combined morphology and immunohistochemistry provides a new approach to the diagnostic workup of adrenal cortical neoplasms, reflecting the evolution of clinical responsibility of pathologists.

本文言語English
ページ(範囲)137-149
ページ数13
ジャーナルEndocrine Pathology
29
2
DOI
出版ステータスPublished - 2018 6 1

ASJC Scopus subject areas

  • 病理学および法医学
  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学

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