Immunohistochemical analysis of insulin-like growth factor 1 and its receptor in sporadic schwannoma/peripheral nerve sheath tumour

Fumiaki Matsubara, Takuyuki Katabami, Shiko Asai, Yasushi Ariizumi, Ichiro Maeda, Masayuki Takagi, May Mc Namara Keely, Katsuhiko Ono, Takashi Maekawa, Yasuhiro Nakamura, Yasushi Tanaka, Hironobu Sasano

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Objective: To investigate the immunohistochemical localization of insulin-like growth factor 1 (IGF-1) and IGF-1 receptor (IGF-1R) in archival specimens of sporadic schwannoma. Method: This study retrospectively analysed the immunolocalization of IGF-1 and IGF-1R in schwannoma specimens collected from all patients with sporadic schwannoma that were treated by two institutions in Japan. The study also evaluated the association between the extent of the IGF-1 and IGF-1R immunoreactivity and several clinicopathological characteristics (age, sex and maximum tumour dimension). Results: The study examined a total of 29 sporadic schwannoma specimens. IGF-1 and IGF-1R immunoreactivity was detected in the majority of the specimens regardless of their anatomical location. IGF-1 and IGF-1R were not co-localized. There was no association between the extent of the IGF-1 and IGF-1R immunoreactivity and the clinicopathological characteristics of the patients. Conclusions: As IGF-1 and IGF-1R immunoreactivity was detected in the majority of sporadic schwannoma specimens regardless of their anatomical location, these findings suggest that an IGF-1/IGF-1R loop could play a role in the tumorigenesis and progression of schwannomas via an autocrine–paracrine mechanism.

本文言語English
ページ(範囲)662-672
ページ数11
ジャーナルJournal of International Medical Research
44
3
DOI
出版ステータスPublished - 2016 6

ASJC Scopus subject areas

  • 生化学
  • 生化学、医学
  • 細胞生物学

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