Immunobiological activities of a chemically synthesized lipid A of Porphyromonas gingivalis

Tomohiko Ogawa, Yasuyuki Asai, Hiroyo Yamamoto, Yasuhiro Taiji, Takayoshi Jinno, Tohru Kodama, Shinjiro Niwata, Hidetoshi Shimauchi, Kuniyasu Ochiai

研究成果: Article査読

24 被引用数 (Scopus)

抄録

A synthetic lipid A of Porphyromonas gingivalis strain 381 (compound PG-381), which is similar to its natural lipid A, demonstrated no or very low endotoxic activities as compared to Escherichia coli-type synthetic lipid A (compound 506). On the other hand, compound PG-381 had stronger hemagglutinating activities on rabbit erythrocytes than compound 506. Compound PG-381 also induced mitogenic responses in spleen cells from lipopolysaccharide (LPS)-hyporesponsive C3H/HeJ mice, as well as LPS-responsive C3H/HeN mice. The addition of polymyxin B resulted in the inhibition of mitogenic activities, however, compound 506 did not show these capacities. Additionally, compound PG-381 showed a lower level of activity in inducing cytokine production in peritoneal macrophages and gingival fibroblasts from C3H/HeN mice, but not C3H/HeJ mice, in comparison to compound 506. Thus, this study demonstrates that the chemical synthesis of lipid A, mimicking the natural lipid A portion of LPS from P. gingivalis, confirms its low endotoxic potency and immunobiological activity. Copyright (C) 2000 Federation of European Microbiological Societies.

本文言語English
ページ(範囲)273-281
ページ数9
ジャーナルFEMS Immunology and Medical Microbiology
28
4
DOI
出版ステータスPublished - 2000 8

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 微生物学
  • 免疫学
  • 微生物学(医療)
  • 感染症

フィンガープリント

「Immunobiological activities of a chemically synthesized lipid A of Porphyromonas gingivalis」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル