@inproceedings{acf23b0d4bcd4c59baf47c3af796ec44,
title = "Immuno-wall lab-on-a-chip protein analysis devices for high precision surgery of gliomas",
abstract = "In the present study, we propose immuno-wall lab-on-a-chip protein analysis devices for ultrarapid detection of R132H mutant isocitrate dehydrogenase 1 (IDH1) that we identified as a specifically and commonly expressed gene in diffusely infiltrative gliomas1. In 9 min immunoassay, we successfully carried out specific detection of R132H mutant IDH1 in a lysate of glioma tissue, which is much faster than intraoperative pathological diagnosis. Moreover, clinical samples from 10 patients with gliomas were analyzed by using the immuno-wall devices. These results were consistent with those of PCR-based genetic mutation detection method. Our devices realize point-of-care tumor testing, resulting in the high precision surgery of gliomas.",
keywords = "Glioma, Immunoassay, Isocitrate dehydrogenase 1, R132h mutation",
author = "T. Kasama and A. Yamamichi and F. Ohka and Y. Kato and H. Suzuki and A. Kato and K. Motomura and M. Hirano and M. Ranjit and L. Chalise and M. Kurimoto and G. Kondo and K. Aoki and N. Kaji and T. Matsubara and H. Suzuki and M. Tokeshi and T. Wakabayashi and A. Natsume and Y. Baba",
year = "2016",
language = "English",
series = "20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016",
publisher = "Chemical and Biological Microsystems Society",
pages = "651--652",
booktitle = "20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016",
note = "20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 ; Conference date: 09-10-2016 Through 13-10-2016",
}