Immuno-wall lab-on-a-chip protein analysis devices for high precision surgery of gliomas

T. Kasama, A. Yamamichi, F. Ohka, Y. Kato, H. Suzuki, A. Kato, K. Motomura, M. Hirano, M. Ranjit, L. Chalise, M. Kurimoto, G. Kondo, K. Aoki, N. Kaji, T. Matsubara, H. Suzuki, M. Tokeshi, T. Wakabayashi, A. Natsume, Y. Baba

研究成果: Conference contribution

抄録

In the present study, we propose immuno-wall lab-on-a-chip protein analysis devices for ultrarapid detection of R132H mutant isocitrate dehydrogenase 1 (IDH1) that we identified as a specifically and commonly expressed gene in diffusely infiltrative gliomas1. In 9 min immunoassay, we successfully carried out specific detection of R132H mutant IDH1 in a lysate of glioma tissue, which is much faster than intraoperative pathological diagnosis. Moreover, clinical samples from 10 patients with gliomas were analyzed by using the immuno-wall devices. These results were consistent with those of PCR-based genetic mutation detection method. Our devices realize point-of-care tumor testing, resulting in the high precision surgery of gliomas.

本文言語English
ホスト出版物のタイトル20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
出版社Chemical and Biological Microsystems Society
ページ651-652
ページ数2
ISBN(電子版)9780979806490
出版ステータスPublished - 2016
イベント20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland
継続期間: 2016 10月 92016 10月 13

出版物シリーズ

名前20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016

Other

Other20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
国/地域Ireland
CityDublin
Period16/10/916/10/13

ASJC Scopus subject areas

  • 制御およびシステム工学

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