抄録
Although recent studies have identified regulatory roles for Foxp3+CD8+ T cells, the mechanisms that induce their development and underlie their functions in vivo have not been elucidated. Here, we show that IL-6 positively regulates the Foxp3+CD8+ T-cell development and function. The Foxp31CD81 T cells that differentiated in vitro in the presence of IL-6 suppressed autoimmune colitis and arthritis in vivo. Moreover, Foxp3+CD8+ T cells that developed in vivo in the presence of enhanced IL-6 signaling suppressed the development of a spontaneous Th17 cell-mediated autoimmune arthritis. Thus, we concluded that Foxp31CD81 T cells develop in response to IL-6 and regulate chronic inflammation in Th17 cell-mediated F759 autoimmune arthritis. These results suggested that Foxp3+CD8+ T cells may develop in response to IL-6 under certain inflammatory conditions in vivo and may regulate some other chronic inflammation diseases.
本文言語 | English |
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論文番号 | dxp119 |
ページ(範囲) | 129-139 |
ページ数 | 11 |
ジャーナル | International immunology |
巻 | 22 |
号 | 2 |
DOI | |
出版ステータス | Published - 2009 12月 30 |
外部発表 | はい |
ASJC Scopus subject areas
- 免疫アレルギー学
- 免疫学