Identifying specific conformations by using a carbohydrate scaffold: Discovery of subtype-selective LPA-receptor agonists and an antagonist

Yoko Tamaruya, Masato Suzuki, Goshu Kamura, Motomu Kanai, Kotaro Hama, Kumiko Shimizu, Junken Aoki, Hiroyuki Arai, Masakatsu Shibasaki

研究成果: Article査読

40 被引用数 (Scopus)

抄録

Stable and potent subtype-selective lysophosphatidic acid (LPA) analogues (agonists and an antagonist) were developed by using carbohydrates as a core structure (see scheme). An array of molecules with the recognition motifs of LPA (a phosphate anion, an oleoyl group, and a hydrogen-bond acceptor) attached to carbohydrate isomers in different three-dimensional arrangements were tested for LPA-receptor activation or inhibition. R = alkyl.

本文言語English
ページ(範囲)2834-2837
ページ数4
ジャーナルAngewandte Chemie - International Edition
43
21
DOI
出版ステータスPublished - 2004 5 17
外部発表はい

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)

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