Identification of tricyclic guanidino compounds from the tetrodotoxin-bearing newt taricha granulosa

Yuta Kudo, Charles T. Hanifin, Mari Yamashita

研究成果: Article査読

抄録

The biosynthesis of the potent neurotoxin tetrodotoxin (TTX, 1) is still unresolved. We used MS-guided screening and nuclear magnetic resonance analyses including long-range HSQMBC to characterize two novel skeletal tricyclic guanidino compounds, Tgr-288 (2a and 2b) and Tgr-210 (3), from the TTX-bearing newt, Taricha granulosa. The presence of these compounds in toxic newts is congruent with a previously proposed pathway for TTX biosynthesis in terrestrial organisms that includes a monoterpene precursor and the production of structurally diversified guanidino compounds.

本文言語English
ページ(範囲)3513-3517
ページ数5
ジャーナルOrganic letters
23
9
DOI
出版ステータスPublished - 2021 5 7

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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