Identification of ST2A1 as a rat brain neurosteroid sulfotransferase mRNA

Miki Shimada, Kouichi Yoshinari, Emi Tanabe, Emi Shimakawa, Maki Kobashi, Kiyoshi Nagata, Yasushi Yamazoe

研究成果: Article査読

30 被引用数 (Scopus)

抄録

A hydroxysteroid sulfotransferase (ST2A1) was identified as a form mediating neurosteroid sulfation in rat brain. The sole expression among known rat ST2A forms was indicated by brain RT-PCR. All nucleotide sequences of seven ST2A cDNA clones isolated from brain matched completely with that of hepatic ST2A1. The recombinant ST2A1 protein mediated neurosteroid sulfation. These data strongly suggest a functional role of ST2A1 as a neurosteroid sulfotransferase in rat brain.

本文言語English
ページ(範囲)222-225
ページ数4
ジャーナルBrain research
920
1-2
DOI
出版ステータスPublished - 2001 11 30

ASJC Scopus subject areas

  • 神経科学(全般)
  • 分子生物学
  • 臨床神経学
  • 発生生物学

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