TY - JOUR
T1 - Identification of sialyl oligosaccharides including an oligosaccharide nucleotide in colostrum of an addax (Addax nasomaculatus) (Subfamily Antelopinae)
AU - Ganzorig, Khuukhenbaatar
AU - Asakawa, Takuya
AU - Sasaki, Masashi
AU - Saito, Tadao
AU - Suzuki, Isao
AU - Fukuda, Kenji
AU - Urashima, Tadasu
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research (C), grant No. 16K08003, from the Japan Society for the Promotion of Science, Sports and Culture (Japan), and a grant from Yotsuba Milk Products Co (Japan).
Publisher Copyright:
© 2017 Japanese Society of Animal Science.
PY - 2018/1
Y1 - 2018/1
N2 - Mammalian milk/colostrum usually contains milk oligosaccharides along with the predominant lactose. Although milk oligosaccharides of a variety of Bovidae species including cow, sheep and goat have been characterized, those of the addax, an Antelopinae species of the Bovidae, have not as yet been clarified. In this study, several sialyl oligosaccharides were purified from a sample of addax colostrum and characterized as follows: Neu5Ac(α2-8)Neu5Ac(α2-3)Gal(β1-4)Glc, Neu5Gc(α2-8)Neu5Gc(α2-3)Gal(β1-4)Glc, Neu5Ac(α2-3)Gal(β1-4)Glc, Neu5Ac(α2-6)Gal(β1-4)GlcNAc, Neu5Gc(α2-3)Gal(β1-4)Glc, Neu5Gc(α2-6)Gal(β1-4)Glc, Neu5Gc(α2-6)Gal(β1-4)GlcNAc. In addition, an oligosaccharide nucleotide Neu5Gc(α2-6)Gal(β1-4)GlcNAcα1-UDP was characterized. Molecular species of a variety of sialyl oligosaccharides found in milk and colostrum of these Bovidae were compared.
AB - Mammalian milk/colostrum usually contains milk oligosaccharides along with the predominant lactose. Although milk oligosaccharides of a variety of Bovidae species including cow, sheep and goat have been characterized, those of the addax, an Antelopinae species of the Bovidae, have not as yet been clarified. In this study, several sialyl oligosaccharides were purified from a sample of addax colostrum and characterized as follows: Neu5Ac(α2-8)Neu5Ac(α2-3)Gal(β1-4)Glc, Neu5Gc(α2-8)Neu5Gc(α2-3)Gal(β1-4)Glc, Neu5Ac(α2-3)Gal(β1-4)Glc, Neu5Ac(α2-6)Gal(β1-4)GlcNAc, Neu5Gc(α2-3)Gal(β1-4)Glc, Neu5Gc(α2-6)Gal(β1-4)Glc, Neu5Gc(α2-6)Gal(β1-4)GlcNAc. In addition, an oligosaccharide nucleotide Neu5Gc(α2-6)Gal(β1-4)GlcNAcα1-UDP was characterized. Molecular species of a variety of sialyl oligosaccharides found in milk and colostrum of these Bovidae were compared.
KW - Bovidae milk oligosaccharides
KW - addax colostrum
KW - milk sugar nucleotide
KW - sialyl milk oligosaccharides
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U2 - 10.1111/asj.12899
DO - 10.1111/asj.12899
M3 - Article
C2 - 28881070
AN - SCOPUS:85028914973
VL - 89
SP - 167
EP - 175
JO - Animal Science Journal
JF - Animal Science Journal
SN - 1344-3941
IS - 1
ER -