Identification of selenoprotein P fragments as a cell-death inhibitory factor

Masaki Hirashima, Takeshi Naruse, Hiroaki Maeda, Chikateru Nozaki, Yoshiro Saito, Kazuhiko Takahashi

研究成果: Article査読

18 被引用数 (Scopus)

抄録

Megakaryoblastoma (Dami cells) cultured in a serum-free medium containing albumin, proliferated for three days but died on the fourth day. This cell death was not observed when human plasma was added, suggesting that human plasma contains a cell-death inhibitory factor. In order to identify this factor, we purified it from human plasma. N-terminal amino acid sequence analysis revealed that this factor is a mixture of C-terminal fragments of selenoprotein P, a major selenocysteine-containing protein in plasma. The specific activity (unit per pmol of selenium) of selenoprotein P fragments protein was 15-fold and 1900-fold higher than that of the full-length SeP and sodium selenite, respectively.

本文言語English
ページ(範囲)794-798
ページ数5
ジャーナルBiological and Pharmaceutical Bulletin
26
6
DOI
出版ステータスPublished - 2003 6
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 薬科学

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