Identification of potential biomarkers of radiation exposure in blood cells by capillary electrophoresis time-of-flight mass spectrometry

Lue Sun, Yohei Inaba, Norie Kanzaki, Mahesh Bekal, Koichi Chida, Takashi Moritake

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Biodosimetry is a useful method for estimating personal exposure doses to ionizing radiation. Studies have identified metabolites in non-cellular biofluids that can be used as markers in biodosimetry. Levels of metabolites in blood cells may reflect health status or environmental stresses differentially. Here, we report changes in the levels of murine blood cell metabolites following exposure to X-rays in vivo. Levels of blood cell metabolites were measured by capillary electrophoresis time-of-flight mass spectrometry. The levels of 100 metabolites were altered substantially following exposure. We identified 2-aminobutyric acid, 2-deoxycytidine, and choline as potentially useful markers of radiation exposure and established a potential prediction panel of the exposure dose using stepwise regression. Levels of blood cell metabolites may be useful biomarkers in estimating exposure doses during unexpected radiation incidents.

本文言語English
論文番号812
ジャーナルInternational journal of molecular sciences
21
3
DOI
出版ステータスPublished - 2020 2月

ASJC Scopus subject areas

  • 触媒
  • 分子生物学
  • 分光学
  • コンピュータ サイエンスの応用
  • 物理化学および理論化学
  • 有機化学
  • 無機化学

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