Identification of pathogenesis-related microRNAs in hepatocellular carcinoma by expression profiling

Yuki Katayama, Moegi Maeda, Ken Miyaguchi, Shota Nemoto, Mahmut Yasen, Shinji Tanaka, Hiroshi Mizushima, Yutaka Fukuoka, Shigeki Arii, Hiroshi Tanaka

研究成果: Article査読

61 被引用数 (Scopus)

抄録

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors of the liver. Since postoperative recurrence and intrahepatic metastases occur frequently, the postoperative 5-year survival rate is low. To investigate the molecular mechanisms of HCC progression, mRNA as well as microRNA (miRNA) expression levels have been profiled in various studies. However, no previous study has comprehensively compared the expression of miRNAs in HCC patients with various clinical features using the tumor and surrounding non-tumor tissues and normal liver samples. In this study, we profiled the expression of miRNAs in tumor and non-tumor tissues from 40 HCC patients with heterogeneous pathogenesis and 6 surrounding non-tumor tissues from patients with metastatic liver cancer. To identify miRNAs specific to each disease state, we comprehensively compared the expression of miRNAs in various combinations. The results indicate that the expression of many known as well as novel miRNAs was altered in patients with the hepatitis C virus infection compared with those with the hepatitis B virus and without any virus infection. The following miRNAs were downregulated in the tumor and non-tumor tissues, and thus could serve as novel biomarkers for chronic liver diseases: miR-18b*, miR-296-5p, miR-557, miR-581, miR-625*, miR-1228, miR-1249 and miR-2116*. Similarly, miR-129*, miR-146b-3p and miR-448 are novel candidates for HCC biomarkers regardless of virus infection.

本文言語English
ページ(範囲)817-823
ページ数7
ジャーナルOncology Letters
4
4
DOI
出版ステータスPublished - 2012 10

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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