Identification of ophiobolin F synthase by a genome mining approach: A sesterterpene synthase from aspergillus clavatus

Ryota Chiba, Atsushi Minami, Katsuya Gomi, Hideaki Oikawa

研究成果: Article査読

98 被引用数 (Scopus)

抄録

During a screening of putative diterpene synthase genes found in public databases using the Aspergillus oryzae expression system, it was found that a single transformant with the ACLA-76850 gene from A. clavatus produced a sesterterpene alcohol, ophiobolin F, and three minor sesterterpene hydrocarbons. The sesterterpene synthase has two catalytically independent domains (prenyltransferase/terpene cyclase) which are homologous to those of diterpene synthase, fusicoccadiene synthase. Coevolution of both domains and reaction mechanisms of these terpene synthases are discussed.

本文言語English
ページ(範囲)594-597
ページ数4
ジャーナルOrganic letters
15
3
DOI
出版ステータスPublished - 2013 2 1

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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