Identification of F-box proteins that are involved in resistance to methylmercury in Saccharomyces cerevisiae

Giwook Hwang, Yosuke Ishida, Akira Naganuma

研究成果: Article査読

21 被引用数 (Scopus)

抄録

We searched for F-box proteins that might be related to the mechanism that protects Saccharomyces cerevisiae against the toxic effects of methylmercury. We found that overexpression of Hrt3 and of Ylr224w rendered yeast cells resistant to methylmercury. Yeast cells that overexpressed Hrt3 and Ylr224w were barely resistant to methylmercury in the presence of a proteasome inhibitor. Our results suggest the existence of some protein(s) that enhances the toxicity of methylmercury in yeast cells and, also, that overexpression of Hrt3 or Ylr224w can confer resistance to methylmercury by enhancing the polyubiquitination of this protein(s) and its degradation in proteasomes.

本文言語English
ページ(範囲)6813-6818
ページ数6
ジャーナルFEBS Letters
580
30
DOI
出版ステータスPublished - 2006 12 22

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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