Identification of cDNA coding for a homologue to mammalian leptin from pufferfish, Takifugu rubripes

Tadahide Kurokawa, Susumu Uji, Tohru Suzuki

研究成果: Article査読

184 被引用数 (Scopus)

抄録

We identified cDNA coding for a homologue to mammalian leptin in puffer, Takifugu rubripes, using genomic synteny around the human leptin gene. In addition to significant sequence homologies, the puffer leptin (pLEP) displays characteristic structural features in common with mammalian leptin. The pLEP mRNA was expressed mostly in the liver that contained abundant lipids. In addition, homologues to pLEP were found in the databanks for three fish species (salmon, medaka, and Tetraodon) and two amphibians (salamander and Xenopus). The phylogenetic analysis shows rapid rates of molecular divergence among leptins from different vertebrate classes, but not between mammals and avians.

本文言語English
ページ(範囲)745-750
ページ数6
ジャーナルPeptides
26
5
DOI
出版ステータスPublished - 2005 5

ASJC Scopus subject areas

  • 生化学
  • 生理学
  • 内分泌学
  • 細胞および分子神経科学

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