Identification of advanced glycation end products of the Maillard reaction in Pick's disease

Takemi Kimura, Kazuyoshi Ikeda, Junichi Takamatsu, Toshio Miyata, Gen Sobue, Taihei Miyakawa, Seikoh Horiuchi

研究成果: Article査読

31 被引用数 (Scopus)

抄録

The recent identification of advanced glycation end products (AGEs) of the Maillard reaction in the central nervous system suggests their potential involvement in the aging process. Other studies have also suggested a possible link between AGEs and Alzheimer's disease, To investigate the role of AGEs in Pick's disease, another neurodegenerative disease associated with dementia, we examined the AGE-immunoreaction in Pick's bodies and ballooned neurons, two characteristic neuropathological features of Pick's disease, using antibodies against identified AGE-structures, N(ε)-(carboxymethyl)lysine and pentosidine. These two structures were observed immunohistochemically in Pick's bodies and ballooned neurons of brain tissues obtained at autopsy from three elderly patients diagnosed with Pick's disease. These immunoreactions were further confirmed by absorption experiments and double-immunostaining. The present findings suggest that AGEs are involved in the pathology of Pick's disease.

本文言語English
ページ(範囲)95-98
ページ数4
ジャーナルNeuroscience Letters
219
2
DOI
出版ステータスPublished - 1996 11月 22
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

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