Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1

Abe Takaaki, Masayuki Kakyo, Taro Tokui, Rie Nakagomi, Toshiyuki Nishio, Daisuke Nakai, Hideki Nomura, Michiaki Unno, Masanori Suzuki, Takeshi Naitoh, Seiki Matsuno, Hiromu Yawo

研究成果: Article査読

478 被引用数 (Scopus)

抄録

We have isolated a novel liver-specific organic anion transporter, LST- 1, that is expressed exclusively in the human, rat, and mouse liver. LST-1 is a new gene family located between the organic anion transporter family and prostaglandin transporter. LST-1 transports taurocholate (K(m) = 13.6 μM) in a sodium-independent manner. LST-1 also shows broad substrate specificity. It transports conjugated steroids (dehydroepiandrosterone sulfate, estradiol- 17β-glucuronide, and estrone-3-sulfate), eicosanoids (prostaglandin E2, thromboxane B2, leukotriene C4, leukotriene E4), and thyroid hormones (thyroxine, K(m) = 3.0 μM and triiodothyronine, K(m) = 2.7 μM), reflecting hepatic multispecificity. LST-1 is probably the most important transporter in human liver for clearance of bile acids and organic anions because hepatic levels of another organic union transporter, OATP, is very low. This is also the first report of the human molecule that transports thyroid hormones.

本文言語English
ページ(範囲)17159-17163
ページ数5
ジャーナルJournal of Biological Chemistry
274
24
DOI
出版ステータスPublished - 1999 6 11

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 細胞生物学

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