TY - JOUR
T1 - Identification of a 910-Kb region of common allelic loss in chromosome bands 16q24.1-q24.2 in human lung cancer
AU - Sato, Masami
AU - Mori, Yuriko
AU - Sakurada, Akira
AU - Fukushige, Shinichi
AU - Ishikawa, Yuichi
AU - Tsuchiya, Eiju
AU - Saito, Yasuki
AU - Nukiwa, Toshihiro
AU - Fujimura, Shigefumi
AU - Horii, Akira
PY - 1998/5
Y1 - 1998/5
N2 - To understand the molecular pathogenesis of human lung cancer, we analyzed allelic deletions on the long arm of chromosome 16 by PCR amplification of microsatellite markers. A total of 203 lung cancer specimens (78 squamous cell carcinomas and 125 adenocarcinomas) were analyzed. In both cell types, a common region of allelic loss was identified in 16q24.1-q24.2; it is flanked by the two markers D16S534 and D16S422 that spanned at most 910 kb. These results were confirmed by fluorescence in situ hybridization. There was no correlation between allelic loss and histopathologic diagnosis or clinical stage. These results suggest the existence of a tumor-suppressor gene that plays an important role in the course of carcinogenesis in both squamous cell carcinoma and adenocarcinoma of the lungs.
AB - To understand the molecular pathogenesis of human lung cancer, we analyzed allelic deletions on the long arm of chromosome 16 by PCR amplification of microsatellite markers. A total of 203 lung cancer specimens (78 squamous cell carcinomas and 125 adenocarcinomas) were analyzed. In both cell types, a common region of allelic loss was identified in 16q24.1-q24.2; it is flanked by the two markers D16S534 and D16S422 that spanned at most 910 kb. These results were confirmed by fluorescence in situ hybridization. There was no correlation between allelic loss and histopathologic diagnosis or clinical stage. These results suggest the existence of a tumor-suppressor gene that plays an important role in the course of carcinogenesis in both squamous cell carcinoma and adenocarcinoma of the lungs.
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U2 - 10.1002/(SICI)1098-2264(199805)22:1<1::AID-GCC1>3.0.CO;2-1
DO - 10.1002/(SICI)1098-2264(199805)22:1<1::AID-GCC1>3.0.CO;2-1
M3 - Article
C2 - 9591628
AN - SCOPUS:0031967882
VL - 22
SP - 1
EP - 8
JO - Genes Chromosomes and Cancer
JF - Genes Chromosomes and Cancer
SN - 1045-2257
IS - 1
ER -