Identification of a 7-cM region of frequent allelic loss on chromosome band 16p13.3 that is specifically associated with anaplastic thyroid carcinoma

Masao Kadota, Yasuhiro Tamaki, Isao Sakita, Yoshifumi Komoike, Michihiko Miyazaki, Masaru Ooka, Norikazu Masuda, Yoshiyuki Fujiwara, Tadashi Ohnishi, Naohiro Tomita, Mitsugu Sekimoto, Masayuki Ohue, Takayuki Ikeda, Tetsuro Kobayashi, Akira Horii, Morito Monden

研究成果: Article査読

13 被引用数 (Scopus)

抄録

A total of 17 primary thyroid cancer specimens including seven anaplastic cancers, two papillary cancers adjacent to the anaplastic cancers, and eight papillary cancers were analyzed for loss of heterozygosity (LOH) on chromosome arm 16p. All tumors of anaplastic cancer showed LOHs at one or more loci, and a 7-cM region of the smallest deleted region was found on 16p13.3 between D16S423 and D16S406. This LOH was specifically found in the anaplastic cancer and not in the papillary thyroid cancer. Our present results suggest localization of the putative tumor suppressor gene on 16p13.3, which is likely to play an important role in the anaplastic transformation of thyroid cancer.

本文言語English
ページ(範囲)529-533
ページ数5
ジャーナルOncology reports
7
3
DOI
出版ステータスPublished - 2000

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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