Ibudilast, a nonselective phosphodiesterase inhibitor, regulates Th1/Th2 balance and NKT cell subset in multiple sclerosis

Juan Feng, Tatsuro Misu, Kazuo Fujihara, Saburo Sakoda, Yuji Nakatsuji, Hikoaki Fukaura, Seiji Kikuchi, Kunio Tashiro, Akio Suzumura, Naoto Ishii, Kazuo Sugamura, Ichiro Nakashima, Yasuto Itoyama

研究成果: Article査読

44 被引用数 (Scopus)

抄録

We investigated the immunoregulatory effects of ibudilast, a nonselective phosphodiesterase inhibitor, at a clinically applicable dose (60 mg/day p.o. for four weeks) in multiple sclerosis (MS) patients. Sensitive real-time PCR for quantifying cytokine mRNA in the blood CD4 + cells revealed that the ibudilast monotherapy significantly reduced tumour necrosis factor-α and interferon (IFN)-γ mRNA and the IFN-γ/interleukin-4 mRNA ratio, suggesting a shift in the cytokine profile from Th1 toward Th2 dominancy. In a flow cytometric analysis, natural killer T cells, which have been reported to relate to Th2 responses in MS and its animal model (experimental autoimmune encephalomyelitis), increased significantly after the therapy. None of the significant immunological changes were seen in healthy subjects or untreated MS patients. lbudilast may be a promising therapy for MS and its clinical effects warrant further study.

本文言語English
ページ(範囲)494-498
ページ数5
ジャーナルMultiple Sclerosis
10
5
DOI
出版ステータスPublished - 2004 10月 1

ASJC Scopus subject areas

  • 神経学
  • 臨床神経学

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