HzAnalyzer: Detection, quantification, and visualization of contiguous homozygosity in high-density genotyping datasets

Todd A. Johnson, Yoshihito Niimura, Hiroshi Tanaka, Yusuke Nakamura, Tatsuhiko Tsunoda

研究成果: Article査読

2 被引用数 (Scopus)

抄録

The analysis of contiguous homozygosity (runs of homozygous loci) in human genotyping datasets is critical in the search for causal disease variants in monogenic disorders, studies of population history and the identification of targets of natural selection. Here, we report methods for extracting homozygous segments from high-density genotyping datasets, quantifying their local genomic structure, identifying outstanding regions within the genome and visualizing results for comparative analysis between population samples.

本文言語English
論文番号R21
ジャーナルGenome biology
12
3
DOI
出版ステータスPublished - 2011 3月 11

ASJC Scopus subject areas

  • 生態、進化、行動および分類学
  • 遺伝学
  • 細胞生物学

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