Hypoxia induces transcription factor ETS-1 via the activity of hypoxia-lnducible factor-1

Manami Oikawa, Mayumi Abe, Hajime Kurosawa, Wataru Hida, Kunio Shirato, Yasufumi Sato

研究成果: Article査読

132 被引用数 (Scopus)

抄録

ETS-1 plays an important role in angiogenesis and cancer invasion, and hypoxia is a common feature in these phenomena. We examined whether hypoxia influenced ETS-1 expression. Hypoxia induced ETS-1 in a human bladder cancer cell line, T24, and promoter analysis revealed that the deletion of -424 to -279 bp from the human ETS-1 promoter decreased the hypoxia-mediated inducibility. This region contained a hypoxia responsive element-like sequence, and HIF-1 bound to it under the hypoxic condition. Double-stranded synthetic oligonucleotides of this sequence as a decoy inhibited the hypoxia-mediated induciblity. These results indicate that hypoxia induces ETS-1 via the activity of HIF-1.

本文言語English
ページ(範囲)39-43
ページ数5
ジャーナルBiochemical and biophysical research communications
289
1
DOI
出版ステータスPublished - 2001 11 23

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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