Hypotensive and heart rate-lowering effects of low-dose bisoprolol determined based on self-measured blood pressure at home

Michihiro Satoh; Taku Obara; Urara Ikeda; Yuka Kobayashi; Hirohito Metoki; Kei Asayama; Masahiro Kikuya; Takayoshi Ohkubo; Yutaka Imai

doi:10.3109/10641963.2012.681085

Hypotensive and heart rate-lowering effects of low-dose bisoprolol determined based on self-measured blood pressure at home

Michihiro Satoh, Taku Obara, Urara Ikeda, Yuka Kobayashi, Hirohito Metoki, Kei Asayama, Masahiro Kikuya, Takayoshi Ohkubo, Yutaka Imai

研究成果: Article › 査読

抄録

We investigated morning home blood pressure (BP)- and heart rate (HR)-lowering effects of 2.5/5 mg bisoprolol in 70 patients with essential hypertension. After 4 weeks of treatment, mean home systolic/diastolic BP and HR significantly decreased by 2.6/5.2 mm Hg and by 8.1 bpm, respectively (all P < .05). The time required to reach 95% of the maximum lowering effect of bisoprolol (stabilizing time) was 5.1 days for home systolic BP (P = .2), 5.1 days for home diastolic BP (P = .0007), and 4.3 days for home HR (P < .0001). We demonstrated that the administration of low-dose bisoprolol significantly and rapidly decreased home BP and HR.

本文言語	English
ページ（範囲）	284-289
ページ数	6
ジャーナル	Clinical and Experimental Hypertension
巻	34
号	4
DOI	https://doi.org/10.3109/10641963.2012.681085
出版ステータス	Published - 2012 7月

ASJC Scopus subject areas

内科学
生理学

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10.3109/10641963.2012.681085

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title = "Hypotensive and heart rate-lowering effects of low-dose bisoprolol determined based on self-measured blood pressure at home",

abstract = "We investigated morning home blood pressure (BP)- and heart rate (HR)-lowering effects of 2.5/5 mg bisoprolol in 70 patients with essential hypertension. After 4 weeks of treatment, mean home systolic/diastolic BP and HR significantly decreased by 2.6/5.2 mm Hg and by 8.1 bpm, respectively (all P < .05). The time required to reach 95% of the maximum lowering effect of bisoprolol (stabilizing time) was 5.1 days for home systolic BP (P = .2), 5.1 days for home diastolic BP (P = .0007), and 4.3 days for home HR (P < .0001). We demonstrated that the administration of low-dose bisoprolol significantly and rapidly decreased home BP and HR.",

keywords = "antihypertensive drug, bisoprolol, home blood pressure, home heart rate, lowering effect, stabilizing time, β-blocker",

author = "Michihiro Satoh and Taku Obara and Urara Ikeda and Yuka Kobayashi and Hirohito Metoki and Kei Asayama and Masahiro Kikuya and Takayoshi Ohkubo and Yutaka Imai",

note = "Funding Information: This study was supported by Grants for Scientific Research (1854042 and 207477) from the Ministry of Education, Culture, Sports, Science and Technology.",

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AU - Satoh, Michihiro

AU - Obara, Taku

AU - Ikeda, Urara

AU - Kobayashi, Yuka

AU - Metoki, Hirohito

AU - Asayama, Kei

AU - Kikuya, Masahiro

AU - Ohkubo, Takayoshi

AU - Imai, Yutaka

N1 - Funding Information: This study was supported by Grants for Scientific Research (1854042 and 207477) from the Ministry of Education, Culture, Sports, Science and Technology.

PY - 2012/7

Y1 - 2012/7

N2 - We investigated morning home blood pressure (BP)- and heart rate (HR)-lowering effects of 2.5/5 mg bisoprolol in 70 patients with essential hypertension. After 4 weeks of treatment, mean home systolic/diastolic BP and HR significantly decreased by 2.6/5.2 mm Hg and by 8.1 bpm, respectively (all P < .05). The time required to reach 95% of the maximum lowering effect of bisoprolol (stabilizing time) was 5.1 days for home systolic BP (P = .2), 5.1 days for home diastolic BP (P = .0007), and 4.3 days for home HR (P < .0001). We demonstrated that the administration of low-dose bisoprolol significantly and rapidly decreased home BP and HR.

AB - We investigated morning home blood pressure (BP)- and heart rate (HR)-lowering effects of 2.5/5 mg bisoprolol in 70 patients with essential hypertension. After 4 weeks of treatment, mean home systolic/diastolic BP and HR significantly decreased by 2.6/5.2 mm Hg and by 8.1 bpm, respectively (all P < .05). The time required to reach 95% of the maximum lowering effect of bisoprolol (stabilizing time) was 5.1 days for home systolic BP (P = .2), 5.1 days for home diastolic BP (P = .0007), and 4.3 days for home HR (P < .0001). We demonstrated that the administration of low-dose bisoprolol significantly and rapidly decreased home BP and HR.

KW - antihypertensive drug

KW - bisoprolol

KW - home blood pressure

KW - home heart rate

KW - lowering effect

KW - stabilizing time

KW - β-blocker

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Hypotensive and heart rate-lowering effects of low-dose bisoprolol determined based on self-measured blood pressure at home

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