Hypofunction in the posterior cingulate gyrus correlates with disorientation for time and place in Alzheimer's disease

Nobutsugu Hirono, Etsuro Mori, Kazunari Ishii, Yoshitaka Ikejiri, Toru Imamura, Tatsuo Shimomura, Mamoru Hashimoto, Hikari Yamashita, Masahiro Sasaki

研究成果: Article査読

64 被引用数 (Scopus)

抄録

The relation between orientation for time and place and regional cerebral glucose metabolism was examined in 86 patients with probable Alzheimer's disease of minimal to moderate severity. Regional glucose metabolic rates in the posterior cingulate gyri and in the right middle temporal gyrus were significantly correlated with temporal orientation, and the glucose metabolic rate in the right posterior cingulate gyrus was significantly correlated with locational orientation irrespective of age, sex, education, and memory impairment. The results suggest that dysfunction of these structures plays an important part in producing disorientation in patients with Alzheimer's disease.

本文言語English
ページ(範囲)552-554
ページ数3
ジャーナルJournal of Neurology Neurosurgery and Psychiatry
64
4
DOI
出版ステータスPublished - 1998 4月
外部発表はい

ASJC Scopus subject areas

  • 外科
  • 臨床神経学
  • 精神医学および精神衛生

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