TY - JOUR
T1 - Hypofunction in the posterior cingulate gyrus correlates with disorientation for time and place in Alzheimer's disease
AU - Hirono, Nobutsugu
AU - Mori, Etsuro
AU - Ishii, Kazunari
AU - Ikejiri, Yoshitaka
AU - Imamura, Toru
AU - Shimomura, Tatsuo
AU - Hashimoto, Mamoru
AU - Yamashita, Hikari
AU - Sasaki, Masahiro
PY - 1998/4
Y1 - 1998/4
N2 - The relation between orientation for time and place and regional cerebral glucose metabolism was examined in 86 patients with probable Alzheimer's disease of minimal to moderate severity. Regional glucose metabolic rates in the posterior cingulate gyri and in the right middle temporal gyrus were significantly correlated with temporal orientation, and the glucose metabolic rate in the right posterior cingulate gyrus was significantly correlated with locational orientation irrespective of age, sex, education, and memory impairment. The results suggest that dysfunction of these structures plays an important part in producing disorientation in patients with Alzheimer's disease.
AB - The relation between orientation for time and place and regional cerebral glucose metabolism was examined in 86 patients with probable Alzheimer's disease of minimal to moderate severity. Regional glucose metabolic rates in the posterior cingulate gyri and in the right middle temporal gyrus were significantly correlated with temporal orientation, and the glucose metabolic rate in the right posterior cingulate gyrus was significantly correlated with locational orientation irrespective of age, sex, education, and memory impairment. The results suggest that dysfunction of these structures plays an important part in producing disorientation in patients with Alzheimer's disease.
KW - Alzheimer's disease
KW - Orientation
KW - Posterior cingulate gyrus
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U2 - 10.1136/jnnp.64.4.552
DO - 10.1136/jnnp.64.4.552
M3 - Article
C2 - 9576555
AN - SCOPUS:0031967611
VL - 64
SP - 552
EP - 554
JO - Journal of Neurology, Neurosurgery and Psychiatry
JF - Journal of Neurology, Neurosurgery and Psychiatry
SN - 0022-3050
IS - 4
ER -
