Hypertension causes exacerbation of chronic kidney disease (CKD) and vice versa. CKD has been known as an independent risk factor for death from cardiovascular disease (CVD). Proteinuria and albuminuria indicate progressive kidney injury and are risk factors for end-stage renal disease(ESRD). Corrections of blood pressure and proteinuria or albuminuria reduce the risk of occurrence of CVD and progression to ESRD. Antihypertensive therapy in CKD includes the management of salt sensitivity and renin angiotensin system. Diuretics more effectively contribute to the balance of sodium and volume of water, when used with ACE inhibitor and ARB. Direct renin inhibitor has been available and shown potential to be a first choice for the treatment of hypertension in CKD.
|ジャーナル||Nihon rinsho. Japanese journal of clinical medicine|
|出版ステータス||Published - 2011 11|
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