Hyperglycemia induced by hippocampal administration of neostigmine is suppressed by intrahypothalamic atropine

A. Iguchi, K. Uemura, Y. Kunoh, H. Miura, T. Ishiguro, K. Nonogaki, T. Tamagawa, M. Gotoh, N. Sakamoto

研究成果: Article査読

15 被引用数 (Scopus)

抄録

We investigated the relationship between the hyperglycemia induced by the administration of neostigmine into the hippocampus and the hypothalamus. Prior to the injection of neostigmine (5×10-8 mol) into the hippocampus, 1 μl each of atropine or hexamethonium (5×10-11-5×10-8 mol) was injected into the bilateral ventromedial hypothalamus (VMH). Atropine suppressed in a dose-dependent manner the hyperglycemia induced by hippocampal administration of neostigmine, whereas hexamethonium had no significant effect. These observations suggest that the pathway for this experimental hyperglycemia involves, at least in part, the muscarinic cholinergic neurons in the VMH.

本文言語English
ページ(範囲)1129-1131
ページ数3
ジャーナルNeuropharmacology
30
10
DOI
出版ステータスPublished - 1991 10月
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 細胞および分子神経科学

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