Human genome and diseases: Review - Immunology and functional genomics of Behçet's disease

M. Zierhut, N. Mizuki, S. Ohno, H. Inoko, A. Gül, K. Onoé, E. Isogai

    研究成果: Review article査読

    107 被引用数 (Scopus)

    抄録

    Behçet's disease (BD) is a multisystemic inflammatory disorder. Although the cause and pathogenesis of BD are still unclear, there is evidence for genetic, immunologic and infectious factors at the onset or in the course of BD. This review focusses on the functional genomics and immunology of BD. HLA-B51 is the major disease susceptibility gene locus in BD. An increased number of γδ T cells in the peripheral blood and in the involved tissues have been reported. However, the T cells at the sites of inflammation appear to be a phenotypically distinct subset. There is also a significant γδ T cell proliferative response to mycobacterial 65-kDa heat shock protein peptides. Homologous peptides derived from the human 60-kDa heat shock protein were observed in BD patients. There is evidence that natural killer T cells may also play a role in BD.

    本文言語English
    ページ(範囲)1903-1922
    ページ数20
    ジャーナルCellular and Molecular Life Sciences
    60
    9
    DOI
    出版ステータスPublished - 2003 9月 1

    ASJC Scopus subject areas

    • 分子医療
    • 分子生物学
    • 薬理学
    • 細胞および分子神経科学
    • 細胞生物学

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