Human genetics, animal models and computer simulations for studying hypertension

Nobuyuki Takahashi, Oliver Smithies

研究成果: Review article査読

57 被引用数 (Scopus)

抄録

Essential hypertension is probably caused by combinations of small quantitative changes in the expression of many genes together with environmental factors. In this article, strategies for studying hypertension using animal models are summarized with emphasis on the combined use of mouse models and computer simulations. We have chosen the rennin-angiotensin system as our main example. Future directions of hypertension research using gene targeting are also discussed.

本文言語English
ページ(範囲)136-145
ページ数10
ジャーナルTrends in Genetics
20
3
DOI
出版ステータスPublished - 2004 3
外部発表はい

ASJC Scopus subject areas

  • 遺伝学

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