Human Gene Therapy for Malignant Gliomas (Glioblastoma Multiforme and Anaplastic Astrocytoma) by In Vivo Transduction with Human Interferon β Gene Using Cationic Liposomes

Jun Yoshida, Masaaki Mizuno, Masazumi Fujii, Yasukazu Kajita, Norimoto Nakahara, Manabu Hatano, Ryuta Saito, Misato Nobayashi, Toshihiko Wakabayashi

研究成果: Article査読

115 被引用数 (Scopus)

抄録

Transfer of interferon β gene via cationic liposomes has been found to induce regression of experimental glioma. We performed a pilot clinical trial of safety and effectiveness of this interferon β gene therapy in five patients with malignant glioma (glioblastoma multiforme or anaplastic astrocytoma). Transgene expression and antitumor activity were detected in four patients. Two patients showed a partial response (>50% tumor reduction) and two others had stable disease 10 weeks after beginning therapy. One patient could not be evaluated because of previous treatment with γ-knife therapy. This study suggests the feasibility and safety of interferon β gene therapy, which may become an important treatment option for patients with malignant glioma.

本文言語English
ページ(範囲)77-86
ページ数10
ジャーナルHuman Gene Therapy
15
1
DOI
出版ステータスPublished - 2004 1月
外部発表はい

ASJC Scopus subject areas

  • 分子医療
  • 分子生物学
  • 遺伝学

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