Human GBP1 Differentially Targets Salmonella and Toxoplasma to License Recognition of Microbial Ligands and Caspase-Mediated Death

Daniel Fisch, Barbara Clough, Marie Charlotte Domart, Vesela Encheva, Hironori Bando, Ambrosius P. Snijders, Lucy M. Collinson, Masahiro Yamamoto, Avinash R. Shenoy, Eva Maria Frickel

研究成果: Article査読

抄録

Fisch et al. find that GBP1 targets Toxoplasma vacuolar and parasite membranes for disruption of both membranes. In contrast, appearance of cytosolic Salmonella is GBP1 independent, but caspase-4 recruitment to bacteria and activation is GBP1 dependent. In a negative feedback loop, caspase-1 cleaves GBP1 and suppresses caspase-4-driven pyroptosis during Salmonella infection.

本文言語English
論文番号108008
ジャーナルCell Reports
32
6
DOI
出版ステータスPublished - 2020 8 11

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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