Human brain natriuretic peptide-like immunoreactivity in human brain

Kazuhiro Takahashi, Kazuhito Totsune, Masahiko Sone, Makoto Ohneda, Osamu Murakami, Keiichi Itoi, Toraichi Mouri

研究成果: Article査読

97 被引用数 (Scopus)

抄録

The presence of immunoreactive human brain natriuretic peptide in the human brain was studied with a specific radioimmunoassay for human brain natriuretic peptide-32. This assay showed no significant cross-reaction with human alpha atrial natriuretic peptide, porcine brain natriuretic peptide or rat brain natriuretic peptide. Immunoreactive human brain natriuretic peptide was found in all 5 regions of human brain examined (cerebral cortex, thalamus, cerebellum, pons and hypothalamus) (0.6-6.7 pmol/g wet weight, n = 3). These values were comparable to the concentrations of immunoreactive alpha atrial natriuretic peptide in human brain (0.5-10.1 pmol/g wet weight). However, Sephadex G-50 column chromatography showed that the immunoreactive human brain natriuretic peptide in the human brain eluted earlier than synthetic human brain natriuretic peptide-32. These findings suggest that human brain natriuretic peptide is present in the human brain mainly as larger molecular weight forms.

本文言語English
ページ(範囲)121-123
ページ数3
ジャーナルPeptides
13
1
DOI
出版ステータスPublished - 1992

ASJC Scopus subject areas

  • 生化学
  • 生理学
  • 内分泌学
  • 細胞および分子神経科学

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