HSC90 is required for nascent hepatitis C virus core protein stability in yeast cells

Naoko Kubota, Yasutaka Inayoshi, Naoko Satoh, Takashi Fukuda, Kenta Iwai, Hiroshi Tomoda, Michinori Kohara, Kazuhiro Kataoka, Akira Shimamoto, Yasuhiro Furuichi, Akio Nomoto, Akira Naganuma, Shusuke Kuge

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Hepatitis C virus core protein (Core) contributes to HCV pathogenicity. Here, we demonstrate that Core impairs growth in budding yeast. We identify HSP90 inhibitors as compounds that reduce intracellular Core protein level and restore yeast growth. Our results suggest that HSC90 (Hsc82) may function in the protection of the nascent Core polypeptide against degradation in yeast and the C-terminal region of Core corresponding to the organelle-interaction domain was responsible for Hsc82-dependent stability. The yeast system may be utilized to select compounds that can direct the C-terminal region to reduce the stability of Core protein. Crown

本文言語English
ページ(範囲)2318-2325
ページ数8
ジャーナルFEBS Letters
586
16
DOI
出版ステータスPublished - 2012 7 30

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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