Hoarseness due to bilateral vocal cord paralysis as an initial manifestation of familial amyotrophic lateral sclerosis

Jiro Fukae, Shin Ichiro Kubo, Nobutaka Hattori, Kaoru Komatsu, Masaaki Kato, Masashi Aoki, Yoshikuni Mizuno

研究成果: Article査読

15 被引用数 (Scopus)

抄録

Bulbar palsy is unusual as an initial manifestation of amyotrophic lateral sclerosis (ALS), although common in the advanced stages. In terms of bulbar palsy as a presenting symptom, dysarthria and dysphagia are of common features. Hoarseness, however, is an initial symptom of ALS in only a small number of patients. We report a 43-year-old female with hoarseness due to bilateral vocal cord paralysis as the first manifestation of ALS. Gene analysis revealed a heterozygous missense mutation in the SOD1 gene, which resulted in an amino acid substitution of isoleucine 149 by threonine. Hoarseness can be the initial symptom of ALS. Therefore, in cases of bilateral vocal cord paralysis of unknown etiology, ALS should be taken into consideration.

本文言語English
ページ(範囲)122-124
ページ数3
ジャーナルAmyotrophic Lateral Sclerosis and Other Motor Neuron Disorders
6
2
DOI
出版ステータスPublished - 2005 6

ASJC Scopus subject areas

  • 臨床神経学

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