Histamine H1 receptor binding capacities in the amygdalas of the amygdaloid kindled rat

H. Toyota, Chihiro Ito, Kazuhiko Yanai, M. Sato, T. Watanabe

研究成果: Article査読

8 被引用数 (Scopus)

抄録

The histamine H1 receptor binding capacity of the amygdalas of amygdaloid kindled rats was studied. In the kindled nonstimulated amygdala, significant decrease in K(D) and B(max) values compared with those of control amygdala were found 1 week after the last kindled seizure. One month after the last kindled seizure, the decreased K(D) value was sustained in the kindled nonstimulated amygdala. This decreased B(max) value 1 week after the last kindled seizure in nonstimulated amygdala seizure susceptibility. The decreased K(D) value in nonstimulated amygdala observed until 1 month after the last kindled seizure indicated the long-lasting increment of binding affinity of the pyrilamine binding site of the histamine H1 receptor in the steady state of kindled seizure susceptibility.

本文言語English
ページ(範囲)2177-2180
ページ数4
ジャーナルJournal of Neurochemistry
72
5
DOI
出版ステータスPublished - 1999 1月 1

ASJC Scopus subject areas

  • 生化学
  • 細胞および分子神経科学

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