Histamine helps development of eczematous lesions in experimental contact dermatitis in mice

Masahiro Seike, Tomoya Takata, Mitsunori Ikeda, Hajime Kodama, Tadashi Terui, Hiroshi Ohtsu

研究成果: Article査読

15 被引用数 (Scopus)

抄録

Histamine is released from mast cells in the skin, causing urticaria and itching. However, little is known about the roles of histamine in development of eczematous lesions in contact dermatitis. Effects of histamine on development of eczematous lesions in contact dermatitis were assessed using histamine-deficient mice in which contact dermatitis was developed by repeated application of diphenylcyclopropenone. Development of eczematous lesions in contact dermatitis was suppressed in histamine-deficient mice compared to wild-type mice. H1 agonist ((6-12-(4-imidazol)ethylamino)-N-(4- trifluoro- methylphenyl)hepatanecarboxamide) promoted development of eczematous lesions in histamine-deficient mice. H1 receptor antagonist (loratadine) suppressed development of eczematous lesions in wild-type mice, whereas H2 agonist (dimaprit) and receptor antagonist (cimetidine) were ineffective. These results suggest that histamine facilitates the development of eczematous lesions in a murine model of contact dermatitis via H1 receptors.

本文言語English
ページ(範囲)68-74
ページ数7
ジャーナルArchives of Dermatological Research
297
2
DOI
出版ステータスPublished - 2005 8 1

ASJC Scopus subject areas

  • Dermatology

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