Histamine depletion in brain caused by treatment with (S) α-fluoromethylhistidine enhances ischemic damage of gerbil hippocampal CA2 neurons

Koreaki Sugimoto, Koji Abe, Tsong Hai Lee, Eiko Sakurai, Kazuhiko Yanai, Kyuya Kogure, Yasuto Itoyama, Takehiko Watanabe

研究成果: Article査読

15 被引用数 (Scopus)

抄録

The effect of (S)α-fluoromethylhistidine (FMH), a specific inhibitor of histamine synthesis from histidine, on ischemic damage was examined in gerbil brain after forebrain ischemia. Two h after subcutaneous FMH injection, the histamine content of the brain was significantly reduced. Neuronal loss in the CA2 region of the hippocampus 7 days after 3 min ischemia was enhanced by treatment with FMH. These results indicate that depletion of brain histamine aggravates neuronal death of hippocampal CA2 neurons after 3 min ischemia.

本文言語English
ページ(範囲)279-283
ページ数5
ジャーナルBrain research
666
2
DOI
出版ステータスPublished - 1994 12 15

ASJC Scopus subject areas

  • 神経科学(全般)
  • 分子生物学
  • 臨床神経学
  • 発生生物学

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