Histamine and Microglia

Tomomitsu Iida, Kazuhiko Yanai, Takeo Yoshikawa

研究成果: Chapter

1 被引用数 (Scopus)


Microglia, a category of glial cells in the central nervous system (CNS), have attracted much attention because of their important role in neuroinflammation. Many translational studies are currently ongoing to discover novel drugs targeting microglia for the treatment of various CNS disorders, such as Alzheimer’s disease, Parkinson’s disease (PD), and depression. Recent studies have shown that brain histamine, a neurotransmitter essential for the regulation of diverse brain functions, controls glial cells and neurons. In vitro studies using primary microglia and microglial cell lines have reported that histamine receptors are expressed in microglia and control microglial functions, including chemotaxis, migration, cytokine secretion, and autophagy. In vivo studies have demonstrated that histamine-related reagents could ameliorate abnormal symptoms in animal models of human diseases, such as amyotrophic lateral sclerosis (ALS), PD, and brain ischemia. Several human studies have revealed alterations in histamine receptor levels in ALS and PD, emphasizing the importance of the CNS histamine system, including histamine-dependent microglial modulation, as a therapeutic target for these disorders. In this review article, we summarize histamine-related research focusing on microglial functions.

ホスト出版物のタイトルCurrent Topics in Behavioral Neurosciences
出版社Springer Science and Business Media Deutschland GmbH
出版ステータスPublished - 2022


名前Current Topics in Behavioral Neurosciences

ASJC Scopus subject areas

  • 行動神経科学


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