Highly potent PDE4 inhibitors with therapeutic potential

Hiroshi Ochiai; Tazumi Ohtani; Akiharu Ishida; Kensuke Kusumi; Masashi Kato; Hiroshi Kohno; Katuya Kishikawa; Takaaki Obata; Hisao Nakai; Masaaki Toda

doi:10.1016/j.bmcl.2003.09.087

Highly potent PDE4 inhibitors with therapeutic potential

Hiroshi Ochiai, Tazumi Ohtani, Akiharu Ishida, Kensuke Kusumi, Masashi Kato, Hiroshi Kohno, Katuya Kishikawa, Takaaki Obata, Hisao Nakai, Masaaki Toda

研究成果: Article › 査読

11 被引用数 (Scopus)

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Based on the hypothesis that the dose-limiting side effects of PDE4 inhibitors could be mediated via the central nervous system (CNS), design and synthesis of a hydrophilic analogue is considered to be one approach to improving the side-effect profile of Ariflo™ 1. Water-soluble piperidine derivatives were found to possess therapeutic potential.

本文言語	English
ページ（範囲）	207-210
ページ数	4
ジャーナル	Bioorganic and Medicinal Chemistry Letters
巻	14
号	1
DOI	https://doi.org/10.1016/j.bmcl.2003.09.087
出版ステータス	Published - 2004 1月 5
外部発表	はい

ASJC Scopus subject areas

生化学
分子医療
分子生物学
薬科学
創薬
臨床生化学
有機化学

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10.1016/j.bmcl.2003.09.087

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AU - Ochiai, Hiroshi

AU - Ohtani, Tazumi

AU - Ishida, Akiharu

AU - Kusumi, Kensuke

AU - Kato, Masashi

AU - Kohno, Hiroshi

AU - Kishikawa, Katuya

AU - Obata, Takaaki

AU - Nakai, Hisao

AU - Toda, Masaaki

PY - 2004/1/5

Y1 - 2004/1/5

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Highly potent PDE4 inhibitors with therapeutic potential

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