Highly efficient synthesis of medium-sized lactams via intramolecular Staudinger-aza-Wittig reaction of ω-azido pentafluorophenyl ester: Synthesis and biological evaluation of LY411575 analogues

Haruhiko Fuwa, Yumiko Okamura, Yuichi Morohashi, Taisuke Tomita, Takeshi Iwatsubo, Toshiyuki Kan, Tohru Fukuyama, Hideaki Natsugari

    研究成果: Article査読

    47 被引用数 (Scopus)

    抄録

    A highly efficient method for the synthesis of medium-sized lactams based on intramolecular Staudinger-aza-Wittig reaction of ω-azido pentafluorophenyl ester has been developed. A variety of 7-10 membered lactams were synthesized in excellent yields. Application of the method to the synthesis of analogues of a potent γ-secretase inhibitor LY411575 and their biological evaluation are also described.

    本文言語English
    ページ(範囲)2323-2326
    ページ数4
    ジャーナルTetrahedron Letters
    45
    11
    DOI
    出版ステータスPublished - 2004 2 8

    ASJC Scopus subject areas

    • 生化学
    • 創薬
    • 有機化学

    フィンガープリント

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