High wall shear stress gradient suppress morphological responses of endothelial cells to fluid flow

M. Sato, N. Saito, N. Sakamoto, T. Ohashi

研究成果: Conference contribution

5 被引用数 (Scopus)

抄録

Arterial bifurcations are known as the common sites for development of cerebral aneurysms. Although localization of aneurysms suggests that high wall shear stress (WSS) and high wall shear stress gradient (WSSG) occurring at the bifurcations may be crucial factors for endothelial dysfunction involved in aneurysm formation, the details of the relationship between the hemodynamic environment and endothelial cell (EC) responses still remain unclear. In this study, we observed morphological responses of ECs under high WSS and high WSSG condition using a T-shaped flow chamber and under high WSS without WSSG condition using a parallel plate flow chamber to evaluate the effects of WSSG to ECs, After 24 h exposure to flow, ECs under high WSS (10 Pa) without WSSG condition oriented perpendicular to the flow, whereas ECs at high WSS (10 Pa) with WSSG condition did not cause EC alignment. After 72 h exposure to flow, ECs exposed to WSSG were not polarized whereas ECs at high WSS without WSSG condition orientated and elongated to the direction of flow. These results indicate that a WSSG may suppress orientation of ECs to the flow direction.

本文言語English
ホスト出版物のタイトルWorld Congress on Medical Physics and Biomedical Engineering
ホスト出版物のサブタイトルImage Processing, Biosignal Processing, Modelling and Simulation, Biomechanics
ページ312-313
ページ数2
4
DOI
出版ステータスPublished - 2009 12 1
イベントWorld Congress on Medical Physics and Biomedical Engineering: Image Processing, Biosignal Processing, Modelling and Simulation, Biomechanics - Munich, Germany
継続期間: 2009 9 72009 9 12

出版物シリーズ

名前IFMBE Proceedings
番号4
25
ISSN(印刷版)1680-0737

Other

OtherWorld Congress on Medical Physics and Biomedical Engineering: Image Processing, Biosignal Processing, Modelling and Simulation, Biomechanics
CountryGermany
CityMunich
Period09/9/709/9/12

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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