High Level Expression of Human α-Fetoprotein in Transgenic Mice

T. Yamashita, N. Kasai, I. Miyoshi, N. Sasaki, K. Maki, M. Sakai, S. Nishi, S. Namioka

研究成果: Article査読

11 被引用数 (Scopus)

抄録

Transgenic mice were produced by the microinjection of the cDNA of human alphafetoprotein (AFP) under control of the enhancer/promoter of the human β-actin gene. Among the 4 mouse lines where the transgene were stable transmitted to the progeny, 3 produced human AFP. The expression was not developmental stage-specific nor tissue-specific as predicted from the properties of enhancer/promoter. The serum human AFP levels of adult mice were 30∼600-fold higher than those of mouse AFP. These mice could be useful for the studies of possible biological functions of AFP during development as well as in malignancies.

本文言語English
ページ(範囲)715-720
ページ数6
ジャーナルBiochemical and biophysical research communications
191
2
DOI
出版ステータスPublished - 1993 3 15
外部発表はい

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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