High frequency of unruptured intracranial aneurysms in female patients with ischaemic heart disease

Toshiyuki Uehara, Masayasu Tabuchi, Etsuro Mori

研究成果: Article査読

10 被引用数 (Scopus)

抄録

Objectives - Concurrence of coronary atherosclerotic lesions and intracranial aneurysms has been pointed out in several postmortem and clinical studies. However, the relative risk for intracranial aneurysms in patients with ischaemic heart disease remains uncertain. The aim of this study is to elucidate clinically whether ischaemic heart disease is a risk factor for intracranial aneurysms. Methods - Between October 1993 and May 1995, 84 patients with ischaemic heart disease with angiographically established coronary artery stenoses who had no history of stroke (ischaemic heart disease group; men:women = 58:26, mean (SD) age = 61.1 (9.6) years) and 200 age matched subjects with minor neurological disorders who had no history of ischaemic heart disease (control group; men:women = 117:83, mean (SD) age = 62.0 (9.2) years) were screened with magnetic resonance angiography (MRA) for the presence of unruptured intracranial aneurysms. For all MRA positive patients, selective angiography was then undertaken. Results - In the ischaemic heart disease group, the frequency of unruptured intracranial aneurysms established angiographically was 3.4% for men and 15.4% for women, compared with 2.6% and 3.6% respectively in the control group. Multiple logistic regression analyses disclosed that ischaemic heart disease was a significant and independent predictor for intracranial aneurysms in women. Conclusions - These results suggest that in women ischaemic heart disease is a risk factor for intracranial aneurysms. Coexistence of intracranial aneurysms should be suspected in women patients with ischaemic heart disease.

本文言語English
ページ(範囲)536-538
ページ数3
ジャーナルJournal of Neurology Neurosurgery and Psychiatry
64
4
DOI
出版ステータスPublished - 1998 4月
外部発表はい

ASJC Scopus subject areas

  • 外科
  • 臨床神経学
  • 精神医学および精神衛生

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