Hepatocyte growth factor induces angiogenesis in injured lungs through mobilizing endothelial progenitor cells

Kota Ishizawa, Hiroshi Kubo, Mitsuhiro Yamada, Seiichi Kobayashi, Takashi Suzuki, Shinya Mizuno, Toshikazu Nakamura, Hidetada Sasaki

研究成果: Article査読

119 被引用数 (Scopus)

抄録

Circulating endothelial progenitor cells (EPCs) play a pivotal role in angiogenesis. Hepatocyte growth factor (HGF) is known to induce proliferation and motility in endothelial cells, and to play a role in mitogenic and morphogenic actions. However, the role of HGF in EPC mobilization has not been clearly described yet. We investigated the effect of HGF on mobilizing EPCs and on angiogenesis in elastase-induced lung injury. HGF significantly increased the triple-positive (Sca-1 +, Flk-1 +, and c-kit +) fraction in peripheral mononuclear cells in mice. The bone marrow-derived cells were recruited into the injured lungs, where they differentiated to capillary endothelial cells. HGF induced proliferation of both bone marrow-derived and resident endothelial cells in the alveolar wall. In conclusion, the present study suggests that HGF induces EPC mobilization from the bone marrow and enhances the proliferation of endothelial cells in vivo. These complex effects induced by HGF orchestrate pulmonary regeneration in emphysematous lung parenchyma.

本文言語English
ページ(範囲)276-280
ページ数5
ジャーナルBiochemical and biophysical research communications
324
1
DOI
出版ステータスPublished - 2004 11月 5

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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