HEN-1, a secretory protein with an LDL receptor motif, regulates sensory integration and learning in Caenorhabditis elegans

Takeshi Ishihara, Yuichi Iino, Akiko Mohri, Ikue Mori, Keiko Gengyo-Ando, Shohei Mitani, Isao Katsura

研究成果: Article査読

123 被引用数 (Scopus)

抄録

Animals sense many environmental stimuli simultaneously and integrate various sensory signals within the nervous system both to generate proper behavioral responses and also to form relevant memories. HEN-1, a secretory protein with an LDL receptor motif, regulates such processes in Caenorhabditis elegans. The hen-1 mutants show defects in the integration of two sensory signals and in behavioral plasticity by paired stimuli, although their sensation capability seems to be identical to that of the wild-type. The HEN-1 protein is expressed in two pairs of neurons, but expression in other neurons is sufficient for wild-type behavior. In addition, expression of HEN-1 at the adult stage is sufficient. Thus, HEN-1 regulates sensory processing non-cell-autonomously in the mature neuronal circuit.

本文言語English
ページ(範囲)639-649
ページ数11
ジャーナルCell
109
5
DOI
出版ステータスPublished - 2002 5月 31
外部発表はい

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

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