TY - JOUR
T1 - HEN-1, a secretory protein with an LDL receptor motif, regulates sensory integration and learning in Caenorhabditis elegans
AU - Ishihara, Takeshi
AU - Iino, Yuichi
AU - Mohri, Akiko
AU - Mori, Ikue
AU - Gengyo-Ando, Keiko
AU - Mitani, Shohei
AU - Katsura, Isao
N1 - Funding Information:
We thank O. Hobert for the ttx-3 mutants, pPDLIM5, pttx-3 plasmids, and AIY markers; A. Fire for the expression vectors; Caenorhabditis Genetic Center for the strains; Y. Kohara for his support in isolation of the deletion mutant and in use of confocal microscope; Y. Suenaga, S. Mochizuki, S. Aihara, and M. Hiyoshi for technical assistance; A. Coulson for the cosmids; and M. Sugiura for secretary assistance. We are also grateful for Y. Sambongi and members of our laboratory for useful suggestions and discussions; O. Hobert, H. Kagoshima, and S. Obara for comments on the manuscript; and H. Kagoshima and I. Kawasaki for naming the mutant hen-1. This work was supported by grants from the Ministry of Education, Culture, Sports, Science, and Technology, Japan.
PY - 2002/5/31
Y1 - 2002/5/31
N2 - Animals sense many environmental stimuli simultaneously and integrate various sensory signals within the nervous system both to generate proper behavioral responses and also to form relevant memories. HEN-1, a secretory protein with an LDL receptor motif, regulates such processes in Caenorhabditis elegans. The hen-1 mutants show defects in the integration of two sensory signals and in behavioral plasticity by paired stimuli, although their sensation capability seems to be identical to that of the wild-type. The HEN-1 protein is expressed in two pairs of neurons, but expression in other neurons is sufficient for wild-type behavior. In addition, expression of HEN-1 at the adult stage is sufficient. Thus, HEN-1 regulates sensory processing non-cell-autonomously in the mature neuronal circuit.
AB - Animals sense many environmental stimuli simultaneously and integrate various sensory signals within the nervous system both to generate proper behavioral responses and also to form relevant memories. HEN-1, a secretory protein with an LDL receptor motif, regulates such processes in Caenorhabditis elegans. The hen-1 mutants show defects in the integration of two sensory signals and in behavioral plasticity by paired stimuli, although their sensation capability seems to be identical to that of the wild-type. The HEN-1 protein is expressed in two pairs of neurons, but expression in other neurons is sufficient for wild-type behavior. In addition, expression of HEN-1 at the adult stage is sufficient. Thus, HEN-1 regulates sensory processing non-cell-autonomously in the mature neuronal circuit.
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U2 - 10.1016/S0092-8674(02)00748-1
DO - 10.1016/S0092-8674(02)00748-1
M3 - Article
C2 - 12062106
AN - SCOPUS:0037205228
VL - 109
SP - 639
EP - 649
JO - Cell
JF - Cell
SN - 0092-8674
IS - 5
ER -